LYMPHOID NEOPLASIA Interleukin-23 acts as antitumor agent on childhood B-acute lymphoblastic leukemia cells
نویسندگان
چکیده
1Associazione Italiana per la Ricerca sul Cancro (AIRC) Laboratory of Immunology and Tumors, Department of Experimental and Laboratory Medicine, G. Gaslini Institute, Genova, Italy; 2Division of Hematology Oncology, Department of Pediatrics, University of Padova, Padova, Italy; 3Department of Oncology and Neurosciences, G. d’Annunzio University and Centro delle Scienze dell’Invecchiamento Aging Research Center, G. d’Annunzio University Foundation, Chieti, Italy; 4Animal Model Facility, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy; 5Department of Human Anatomy and Histology, University of Bari, Bari, Italy; and 6Laboratory of Oncology, G. Gaslini Institute, Genova, Italy
منابع مشابه
Interleukin-23 acts as antitumor agent on childhood B-acute lymphoblastic leukemia cells.
Interleukin (IL)-23 is a proinflammatory cytokine belonging to the IL-12 superfamily. The antitumor activity of IL-23 is controversial, and it is unknown whether or not the cytokine can act directly on tumor cells. The aim of this study was to investigate the potential direct antitumor activity of IL-23 in pediatric B-acute lymphoblastic leukemia (B-ALL) cells and to unravel the molecular mecha...
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تاریخ انتشار 2010